Thrift Drug was a U.S. pharmacy chain founded in 1935 and based in Pittsburgh, Pennsylvania.
The company was purchased by JCPenney in 1968, and was expanded greatly thereafter, serving as the flagship chain of JCPenney's pharmacy group. The chain did not hide its affiliation with JCPenney, as it had JCPenney catalog merchandise pickup centers inside many of its locations, as well as signs advertising "JCPenney Catalog Center". Stores also accepted the JCPenney credit card for purchases.